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Macrophages and Dendritic Cells in the Post-testicular Environment

机译:睾丸后环境中的巨噬细胞和树突状细胞

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摘要

Macrophages (Mϕ) and dendritic cells (DCs) are heterogeneous families of functionally and developmentally related immune cells that play crucial roles in tissue homeostasis and regulation of immune responses. In the past 5 years, immunologists have generated a considerable amount of data that challenged dogmas about the ontogeny and functions of these highly versatile cells. The male excurrent duct system plays a critical role in the establishment of fertility by allowing sperm maturation, transport and storage. In addition, it is challenged by pathogens and must establish a protective and tolerogenic environment for a continuous flow of autoantigenic spermatozoa. The post-testicular environment, and particularly the epididymis, contains an intricate network of DCs and Mϕ; however, the immunophysiology of this intriguing and highly specialized mucosal system is poorly understood. This review summarizes the current trends in mouse Mϕ and DC biology and speculates about their roles in the steady state epididymis. Unraveling immune cell functions in the male reproductive tract is an essential prerequisite for the design of innovative strategies aiming at controlling male fertility and treating infertility.
机译:巨噬细胞(Mϕ)和树突状细胞(DC)是功能和发育相关的免疫细胞的异质家族,在组织体内稳态和免疫应答的调节中起着至关重要的作用。在过去的5年中,免疫学家已经获得了大量数据,这些数据就这些高度通用的细胞的个体发育和功能向教条提出了挑战。雄性前导管系统通过允许精子成熟,运输和储存,在建立生育能力中起着至关重要的作用。另外,它受到病原体的挑战,必须为连续不断产生自身抗原的精子建立保护和耐受环境。睾丸后的环境,尤其是附睾,包含一个复杂的DC和Mϕ网络。但是,人们对这种有趣且高度专业化的粘膜系统的免疫生理学知之甚少。这篇综述总结了小鼠Mϕ和DC生物学的当前趋势,并推测了它们在稳态附睾中的作用。揭示男性生殖道中的免疫细胞功能是设计旨在控制男性生育力和治疗不育症的创新策略的必要前提。

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  • 期刊名称 other
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  • 年(卷),期 -1(363),1
  • 年度 -1
  • 页码 97–104
  • 总页数 15
  • 原文格式 PDF
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