CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats

摘要

RationaleUnder some conditions stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a sub-threshold cocaine dose. The mechanisms responsible for stress-potentiated reinstatement are not well-defined. Endocannabinoid signaling is increased by stress and regulates synaptic transmission in brain regions implicated in motivated behavior.