β-C(sp3)-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

摘要

The Pd(II)-catalyzed intermolecular arylation of unactivated β-C(sp³)-H bonds in α-hydroxy acid derivatives was achieved. A variety of aryl iodides was tolerated giving moderate to good yields. The feasibility of amino acid auxiliary as a directing group was demonstrated