DERIVATIVES OF AMINO-BENZOIC ACIDS, HYDROXY BENZOIC ACIDS, CINNAMIC ACIDS, UROCANIC ACID AND BENZIMIDAZOLE, WHETHER OR NOT CONTAINING AN AMINO ACID GROUP ABSORBING UVB AND / OR UVA AND FOR AVOIDING PHOTODERMATOSES, IN HUMANS, CONSECUTIVE TO THE ADMINISTRATION OF MEDICINAL PRODUCTS, THE USE OF PERFUME COSMETICS OR FRAGRANCES

摘要

P Amino benzoic acids, hydroxybenzoic acids, cinnamic acids, urocanic acid and benzimidazole derivatives have been synthesized. The photoprotective power of each class of compounds has been tested. It stems from 4 different isolated or joint mechanisms. BR/ mechanism 1: absorption of ultraviolet radiation between 360 nm and 260 nm (UVB and / or UVA) BR/ mechanism 2: prolonged absorption of ultraviolet radiations between 360 nm and 260 nm by preferential fixation and prolonged at the level of the epidermis of the human skin of the compound and this by the introduction into their chemical structure of amino acid groups, peptides, sulfur or not. BR/ mechanism 3: induction of melanogenesis, natural protective system of the skin. BR/ mechanism 4: choice of a compound that is either liposoluble or water-soluble depending on the dosage form (emulsion or spray). The present invention claims, the synthesis of various compounds, the photoprotective activity and the use of all the compounds described in order to avoid photodermatoses resulting from the administration of medicaments, the use of cosmetics and / or or perfumes in humans. / P