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The Fine–Gray Model Under Interval Censored Competing Risks Data

机译:区间删失竞争风险数据下的精细灰色模型

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摘要

We consider semiparametric analysis of competing risks data subject to mixed case interval censoring. The Fine–Gray model () is used to model the cumulative incidence function and is coupled with sieve semiparametric maximum likelihood estimation based on univariate or multivariate likelihood. The univariate likelihood of cause-specific data enables separate estimation of cumulative incidence function for each competing risk, in contrast with the multivariate likelihood of full data which estimates cumulative incidence functions for multiple competing risks jointly. Under both likelihoods and certain regularity conditions, we show that the regression parameter estimator is asymptotically normal and semiparametrically efficient, although the spline-based sieve estimator of the baseline cumulative subdistribution hazard converges at a rate slower than root-n. The proposed method is evaluated by simulation studies regarding its finite sample performance and is illustrated by a competing risk analysis of data from an dementia cohort study.
机译:我们考虑受混合案例间隔审查的竞争风险数据的半参数分析。 Fine-Gray模型()用于对累积入射函数进行建模,并与基于单变量或多变量似然的筛网半参数最大似然估计结合。特定原因原因数据的单变量可能性使得可以分别估计每个竞争风险的累积发生率函数,而全数据的多元可能性则可以共同估计多个竞争风险的累积发生率函数。在可能性和某些规律性条件下,尽管基线累积子分布危害的基于样条的筛估计器的收敛速度比根n慢,但我们显示回归参数估计器是渐近正态和半参数有效的。通过模拟研究对其有限样本性能进行评估,并通过对老年痴呆队列研究数据的竞争性风险分析进行了说明。

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