Comparison of Realistic and Idealized Breathing Patterns in Computational Models of Airflow and Vapor Dosimetry in the Rodent Upper Respiratory Tract

摘要

ContextComputational fluid dynamics (CFD) simulations of airflows coupled with physiologically-based pharmacokinetic (PBPK) modeling of respiratory tissue doses of airborne materials have traditionally used either steady-state inhalation or a sinusoidal approximation of the breathing cycle for airflow simulations despite their differences from normal breathing patterns.