Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis

摘要

BackgroundIn the vertebrate retina six neuronal and one glial cell class are produced from a common progenitor pool. During neurogenesis, adjacent retinal cells use Notch signaling to maintain a pool of progenitors by blocking particular cells from differentiating prematurely. In mice there are multiple Notch pathway ligands and receptors, but the role(s) of each paralogue during retinal histogenesis remains only partially defined.