The discovery and validation of biomarkers for the diagnosis of esophageal squamous dysplasia and squamous cell carcinoma

摘要

BackgroundThe 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are squamous cell carcinomas (ESCC). Endoscopic screening is not feasible on the scale required however non-endoscopic cell-sampling techniques may be feasible. Coupling endoscopic biopsies or non-endoscopic samples with biomarker analysis could reduce the subjectivity associated with both methods and thus improve diagnostic accuracy. The aims of this study were therefore to identify biomarkers for esophageal squamous dysplasia and carcinoma.