Pulsatile Load Components Resistive Load and Incident Heart Failure: The Multi Ethnic Study of Atherosclerosis (MESA)

摘要

BackgroundLeft Ventricular (LV) afterload is composed of systemic vascular resistance (SVR) and components of pulsatile load, including total arterial compliance (TAC) and reflection magnitude (RM). RM, which impacts the LV systolic loading sequence, has been shown to strongly predict HF. Effective arterial elastance is a commonly used parameter initially proposed to be a lumped index of resistive and pulsatile afterload. We sought to assess how various LV afterload parameters predict heart failure (HF) risk and whether RM predicts HF independent of subclinical atherosclerosis.