Therapeutic benefits of SYK inhibitor administration on binge drinking-induced alcoholic liver injury steatosis and inflammation in mice

摘要

BackgroundBinge drinking is increasingly recognized as an important cause of liver disease with limited therapeutic options for patients. Binge alcohol use, similar to chronic alcohol consumption, induces numerous deregulated signaling events that drive liver damage, steatosis and inflammation. In this report, we evaluated the role of spleen tyrosine kinase (SYK), which modulates numerous signaling events previously identified linked in the development alcohol-induced liver pathology.