Post-exposure Prophylaxis after Hepatitis C Occupational Exposure in the Interferon-free Era

摘要

Purpose of reviewHealthcare personnel are at risk for occupational exposures to bloodborne pathogens. Primary prevention remains the first line of defense, but secondary prevention measures known to be effective should be implemented when percutaneous exposures occur. Hepatitis C virus (HCV) is a major infectious cause of liver-related morbidity and mortality. Chronic HCV treatment has changed dramatically, with many all-oral directly acting anti-HCV antiviral (DAA) regimens now available. Evidence for the use of DAAs as post-exposure prophylaxis (PEP) after occupational exposures to HCV is summarized here.