Stereocontrolled Syntheses of Seven-membered Carbocycles via Tandem Allene Aziridination/4 + 3 Reaction

摘要

A tandem allene aziridination/[4+3]/reduction sequence converts simple homoallenic sulfamates to densely functionalized aminated cycloheptenes, where the relative stereochemistry at five contiguous asymmetric centers can be controlled through the choice of the solvent and the reductant. The products resulting from this chemistry can be readily transformed into complex molecular scaffolds that contain up to seven contiguous stereocenters.