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Anti-leukemia efficacy and mechanisms of action of SL-101 a novel anti-CD123 antibody-conjugate in acute myeloid leukemia

机译：新型抗CD123抗体缀合物SL-101在急性髓样白血病中的抗白血病功效和作用机制

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PurposeThe persistence of leukemia stem cells (LSC)-containing cells after induction therapy may contribute to minimal residual disease (MRD) and relapse in acute myeloid leukemia (AML). We investigated the clinical relevance of CD34⁺CD123⁺ LSC-containing cells and anti-leukemia potency of a novel antibody-conjugate SL-101 in targeting CD123⁺ LSCs.

机译：目的诱导治疗后含白血病干细胞（LSC）的细胞的持久性可能有助于最小程度的残留疾病（MRD）和急性髓细胞性白血病（AML）的复发。我们调查了含有CD34 ^{+ CD123 ^{+ LSC的细胞的临床相关性以及新型抗体偶联物SL-101靶向CD123 ^{+ < / sup> LSC。}}}

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期刊名称 other
作者
Lina Han; Jeffrey L Jorgensen; Chris Brooks; Ce Shi; Qi Zhang; Graciela M. Nogueras González; Antonio Cavazos; Rongqing Pan; Hong Mu; Sa A Wang; Jin Zhou; Gheath AI-Atrash; Stefan O. Ciurea; Mike Rettig; John F. DiPersio; Jorge Cortes; Xuelin Huang; Hagop M Kantarjian; Michael Andreeff; Farhad Ravandi; Marina Konopleva;
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年(卷),期 -1(23),13
年度 -1
页码 3385–3395
总页数 22
原文格式 PDF
正文语种
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关键词
acute myeloid leukemia CD123 leukemia stem cell SL-101 minimal residual disease;

机译：急性髓细胞性白血病;CD123;白血病干细胞;SL-101;最小残留病;

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专利

1. Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia [J] . Han Lina, Jorgensen Jeffrey L., Brooks Chris, Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第13期

机译：SL-101的抗血清血症和作用机制，一种新的抗CD123抗体缀合物，急性髓性白血病
2. Abivertinib, a novel BTK inhibitor: Anti-Leukemia effects and synergistic efficacy with homoharringtonine in acute myeloid leukemia [J] . Huang Shujuan, Pan Jiajia, Jin Jing, Cancer letters . 2019,第期

机译：Abivertinib，一种新的BTK抑制剂：抗白血病效应和同源骨髓细胞中的抗白血病效应和协同疗效在急性髓性白血病中
3. Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models [J] . Han Lina, Zhang Qi, Shi Ce, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：用Cobimetinib（GDC-0973）靶向MAPK信号通路（GDC-0973）增强昆虫菌（ABT-199 / GDC-0199）的抗白血病疗效在急性髓性白血病模型中
4. K-Means Clustering on 3^rd order polynomial based normalization of Acute Myeloid Leukemia (AML) and Acute Lymphocyte Leukemia (ALL) [C] . Mehdi A.M., Sehgal M.S., Zayegh A., Electrical Engineering, 2009. ICEE '09 . 2009

机译：基于3 ^{rd 多项式的K均值聚类基于急性髓细胞白血病（AML）和急性淋巴细胞白血病（ALL）的归一化}
5. Loss of Egr1 plays a role in murine leukemogenesis and may play a role in the development of acute myeloid leukemia and therapy-related acute myeloid leukemia. [D] . Joslin, John M. 2006

机译：Egr1的丢失在小鼠白血病的发生中起作用，并且可能在急性髓细胞性白血病和与治疗有关的急性髓细胞性白血病的发展中起作用。
6. Natural Products and Acute Myeloid Leukemia: A Review Highlighting Mechanisms of Action [O] . Dongwon Hwang, Minsun Kim, Hyejin Park, 2019

机译：天然产物和急性髓性白血病：回顾突出作用机制。
7. Anti-leukemia efficacy and mechanisms of action of SL-101, a novel anti-CD123 antibody-conjugate in acute myeloid leukemia [O] . Lina Han, Eric Rowinsky, Chris Brooks, 2015

机译：抗白血病疗效和SL-101的作用机制，在急性髓性白血病中新型抗CD123抗体 - 缀合物

Anti-leukemia efficacy and mechanisms of action of SL-101 a novel anti-CD123 antibody-conjugate in acute myeloid leukemia

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