Synthesis of Cyclooxygenase Metabolites of 89-Epoxyeicosatrienoic Acid (EET): 11- and 15-Hydroxy 89-EETs

摘要

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.