Mild Redox-Neutral Formylation of Aryl Chlorides via Photocatalytic Generation of Chlorine Radicals

摘要

We report a redox-neutral formylation of aryl chlorides that proceeds through selective 2-functionalization of 1,3-dioxolane via nickel and photoredox catalysis. This scalable, benchtop approach provides a distinct advantage over traditional reductive carbonylation in that no carbon monoxide, pressurized gas, or stoichiometric reductant is employed. Mild conditions enable unprecedented scope from abundant and complex aryl chloride starting materials.