Population specific resequencing associates the ATP Binding Cassette Subfamily C Member 4 (ABCC4) gene with gout in New Zealand Māori and Pacific men

摘要

ObjectiveThere is no evidence for genetic association of the organic anion transporters (OAT) 1–3 (SLC22A6, SLC22A7, SLC22A8) and multi-drug resistance protein 4 (MRP4; ABCC4) with serum urate or gout. The Māori and Pacific (Polynesian) population of New Zealand (NZ) has the highest prevalence of gout worldwide. Our aim was to determine if there were any Polynesian population-specific genetic variants in the SLC22A6-8 and ABCC4 genes associated with gout.