Upward drift in CSF Aβ42 assay values over 10 years

摘要

INTRODUCTIONThe best established cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) are levels of amyloid-β 42 (Aβ42), total tau (tau) and phosphorylated tau-181 (ptau). We examined whether a widely used commercial immunoassay for CSF Aβ42, tau and ptau provided stable measurements over ~10 years.