Tandem repeat variation near the HIC1 promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

摘要

BackgroundThe hypermethylated in cancer 1/Sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin-induced damage repair system. Based on prior evidence that the variable number of tandem repeat (VNTR) sequence located near the promoter lesion of HIC1 is associated with HIC1 gene expression, we tested the hypothesis that this VNTR is associated with clinical outcome in metastatic colorectal cancer (mCRC) patients receiving oxaliplatin-based chemotherapy.