Genetic polymorphism of the methotrexate transporter ABCG2 blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study

摘要

PurposeMethotrexate (MTX) treatment is associated with lower blood pressure (BP) and arterial stiffness in rheumatoid arthritis (RA). We investigated associations between single-nucleotide polymorphism (SNP) of the ATP-binding cassette efflux transporter gene ABCG2 (rs2231142), BP, and arterial stiffness in RA patients treated with MTX.