Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next generation sequencing in European Americans with multiple sclerosis.

摘要

BackgroundThe association between HLA-DRB1*15:01 with multiple sclerosis (MS) susceptibility is well established but the contribution of the tightly associated HLA-DRB5*01:01 allele has not yet been completely ascertained. Similarly, the effects of HLA-DRB1*04:01 alleles and haplotypes, defined at the full gene resolution level, with MS risk remains to be elucidated.