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Factor XII Deficiency Mimicking Bleeding Diathesis: A Unique Presentation and Diagnostic Pitfall

机译:凝血因子XII缺乏症模拟出血素质:独特的表现和诊断误区

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摘要

Factor XII (FXII), also known as Hageman factor, is a coagulation protein that is necessary for the functioning of the intrinsic coagulation cascade and fibrin formation. When deficient, it results in a significant prolongation of activated partial thromboplastin time (aPTT), mimicking a bleeding disorder. However, it does not result in clinical bleeding tendency. We report a case of an elderly male who was found to have prolonged aPTT, discovered during preoperative evaluation for operative repair of hip fracture. Although laboratory investigation was suggestive of bleeding tendency, he was diagnosed with factor XII deficiency and had no bleeding complications intra-operatively or in the post-operative period.
机译:因子XII(FXII),也称为哈格曼因子(Hageman factor),是内在的凝血级联和纤维蛋白形成的功能所必需的凝血蛋白。不足时,它会导致活化的部分凝血活酶时间(aPTT)显着延长,从而模仿出血性疾病。但是,这不会导致临床出血倾向。我们报告一例老年男性,发现其aPTT延长,在术前评估髋部骨折的术前评估中发现。尽管实验室检查提示有出血倾向,但他被诊断出缺乏XII因子,并且术中或术后无出血并发症。

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