Diagnostic method of bovine blood coagulation factor XI deficiency

摘要

It provides diagnostic kits and diagnostic methods of bovine blood coagulation Factor XI deficiency with an indicator of genetic polymorphisms of genes to identify the gene encoding the bovine blood coagulation factor XI, encoding bovine blood coagulation Factor XI For the purpose to be, to achieve this end, in exon 9 of the gene encoding a blood coagulation factor XI, as an indication whether it is replaced by a nucleotide sequence base c fifth is shown in atatgtgcagaatata , diagnosing test cattle whether suffering from blood coagulation factor XI deficiency, for example, within exon 9, the presence or absence of substitution in exon 9, the base represented by atatgtgcagaatata or region comprising a nucleotide c fifth to perform a nucleic acid amplification reaction using a primer capable of amplifying a region comprising the sequence, and detecting the presence or absence based on the amplified fragment, the nucleotide sequence or the base length.