Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal derived interferonkappa

摘要

Objective:Skin inflammation and photosensitivity are common in cutaneous (CLE) and systemic lupus erythematosus (SLE) patients, yet little is known about the mechanisms that regulate these traits. Here we investigate the role of interferon kappa (IFN-κ) in regulation of type I IFN and photosensitive responses and examine its dysregulation in lupus skin.