Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

摘要

Objective Skin inflammation and photosensitivity are common in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known about the mechanisms that regulate these traits. Here we investigate the role of interferon kappa (IFN-kappa) in regulation of type I interferon (IFN) and photosensitive responses and examine its dysregulation in lupus skin.