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A Sorting Statistic with Application in Neurological Magnetic Resonance Imaging of Autism

机译:分类统计及其在自闭症神经磁共振成像中的应用

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摘要

Effect size refers to the assessment of the extent of differences between two groups of samples on a single measurement. Assessing effect size in medical research is typically accomplished with Cohen's d statistic. Cohen's d statistic assumes that average values are good estimators of the position of a distribution of numbers and also assumes Gaussian (or bell-shaped) underlying data distributions. In this paper, we present an alternative evaluative statistic that can quantify differences between two data distributions in a manner that is similar to traditional effect size calculations; however, the proposed approach avoids making assumptions regarding the shape of the underlying data distribution. The proposed sorting statistic is compared with Cohen's d statistic and is demonstrated to be capable of identifying feature measurements of potential interest for which Cohen's d statistic implies the measurement would be of little use. This proposed sorting statistic has been evaluated on a large clinical autism dataset from Boston Children's Hospital, Harvard Medical School, demonstrating that it can potentially play a constructive role in future healthcare technologies.
机译:效应大小是指在单次测量中评估两组样本之间差异的程度。通常使用Cohen的d统计量来评估医学研究中的效应量。 Cohen的d统计量假设平均值是数字分布位置的良好估计,并且还假设基础数据分布为高斯(或钟形)。在本文中,我们提出了一种替代的评估统计量,它可以以类似于传统效应量计算的方式量化两个数据分布之间的差异。但是,建议的方法避免对基础数据分布的形状进行假设。拟议的排序统计量与Cohen的d统计量进行了比较,并证明能够识别潜在兴趣的特征度量,而Cohen的d统计量暗示该度量用处不大。这项拟议的分类统计数据已在哈佛医学院波士顿儿童医院的大型临床自闭症数据集上进行了评估,表明其可能在未来的医疗技术中发挥建设性作用。

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