INHIBITION OF PAI-1 IMPROVES BRAIN COLLATERAL PERFUSION AND INJURY AFTER ACUTE ISCHEMIC STROKE IN AGED HYPERTENSIVE RATS

摘要

Background and Purpose –Aging and hypertension, co-morbidities prevalent in the stroke population, are associated with poor collateral status and worsened stroke outcome. However, underlying mechanisms by which these conditions affect stroke outcome are not clear. We studied the role of plasminogen activator inhibitor-1 (PAI-1) that is increased in aging and hypertension on brain and vascular expression of inflammatory factors and perfusion that may contribute to worse stroke outcomes.