Is Cerebellar Ataxia Neuropathy and Vestibular Areflexia Syndrome (CANVAS) a Vestibular Ganglionopathy?

摘要

OBJECTIVESCANVAS is an acronym for cerebellar ataxia, neuropathy and vestibular areflexia syndrome. Limited autopsy data has suggested that CANVAS is caused by a focal dorsal root ganglionopathy that damages Scarpa’s (vestibular) ganglion, but spares the Spiral (hearing) ganglion. If the vestibular areflexia of CANVAS is in fact due to ganglionopathy, then there should be global reduction of all vestibular responses.