Whole‐body Autoradiography of Tumor‐bearing Hamsters with a New Tumor Imaging Agent Indium‐111‐labeled Porphyrin

摘要

We have synthesized a new tumor imaging agent, ¹¹¹In‐labeled porphyrin (¹¹¹In‐ATN‐2). In order to image transplantable pancreatic carcinoma in Syrian golden hamsters, we investigated the biodistribution of ¹¹¹In‐ATN‐2 72 hr after injecting the agent by means of whole‐body autoradiography. The efficacy of the agent was compared with that of ⁶⁷Ga citrate. The images with ¹¹¹In‐ATN‐2 were found to be clearer than those with ⁶⁷Ga citrate. Tumor‐to‐tissue radiodistribution ratios of the former were higher than those of the latter. Thus, ¹¹¹In‐ATN‐2 seems to be more useful for tumor diagnosis.