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PROPAGATED REPOLARIZATION IN HEART MUSCLE

机译:肌肉中的再极化

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摘要

The effect of current flow on the transmembrane action potential of single fibers of ventricular muscle has been examined. Pulses of repolarizing current applied during the plateau of the action potential displace membrane potential much more than do pulses of depolarizing current. The application of sufficiently strong pulses of repolarizing current initiates sustained repolarization which persists after the end of the pulse. This sustained repolarization appears to propagate throughout the length of the fiber. Demonstration of propagated repolarization is made difficult by appearance of break excitation at the end of the repolarizing pulse. The thresholds for sustained repolarization and break excitation are separated by reducing the concentration of Ca++ in the environment of the fiber. In fibers in such an environment it is easier to demonstrate apparently propagated repolarization and also, by further increase of the strength of the repolarizing current, to demonstrate graded break excitation.
机译:研究了电流对心室肌单纤维跨膜动作电位的影响。在动作电位的稳定期期间施加的重新极化电流的脉冲使膜电位移位的程度远远大于去极化电流的脉冲。施加足够强的复极化电流脉冲会启动持续的复极化,该复极化在脉冲结束后仍然存在。这种持续的极化作用似乎在纤维的整个长度上传播。由于在重新极化脉冲的末尾出现了断续激励,很难证明传播的重新极化。通过降低纤维环境中Ca ++ 的浓度来分隔持续极化和断裂激发的阈值。在这种环境下的光纤中,更容易表现出明显传播的复极化,并且通过进一步增加复极化电流的强度,也易于表现出分级的断裂激发。

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