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Inhibition of the compound action potentials of frog sciatic nerves by aroma oil compounds having various chemical structures

机译:具有各种化学结构的芳香油化合物抑制青蛙坐骨神经的复合动作电位

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摘要

Plant-derived chemicals including aroma oil compounds have an ability to inhibit nerve conduction and modulate transient receptor potential (TRP) channels. Although applying aroma oils to the skin produces a local anesthetic effect, this has not been yet examined throughly. The aim of the present study was to know how nerve conduction inhibitions by aroma oil compounds are related to their chemical structures and whether these activities are mediated by TRP activation. Compound action potentials (CAPs) were recorded from the frog sciatic nerve by using the air-gap method. Citral (aldehyde), which activates various types of TRP channels, attenuated the peak amplitude of CAP with the half-maximal inhibitory concentration (IC50) value of 0.46 mmol/L. Another aldehyde (citronellal), alcohol (citronellol, geraniol, (±)-linalool, (−)-linalool, (+)-borneol, (−)-borneol, α-terpineol), ester (geranyl acetate, linalyl acetate, bornyl acetate), and oxide (rose oxide) compounds also reduced CAP peak amplitudes (IC50: 0.50, 0.35, 0.53, 1.7, 2.0, 1.5, 2.3, 2.7, 0.51, 0.71, 0.44, and 2.6 mmol/L, respectively). On the other hand, the amplitudes were reduced by a small extent by hydrocarbons (myrcene and p-cymene) and ketone (camphor) at high concentrations (2–5 mmol/L). The activities of citral and other TRP agonists ((+)-borneol and camphor) were resistant to TRP antagonist ruthenium red. An efficacy sequence for the CAP inhibitions was generally aldehydes ≥ esters ≥ alcohols > oxides >> hydrocarbons. The CAP inhibition by the aroma oil compound was not related to its octanol–water partition coefficient. It is suggested that aroma oil compounds inhibit nerve conduction in a manner specific to their chemical structures without TRP activation.
机译:包括芳香油化合物在内的植物来源的化学物质具有抑制神经传导和调节瞬时受体电位(TRP)通道的能力。尽管将香精油涂在皮肤上会产生局部麻醉作用,但尚未对此进行全面检查。本研究的目的是了解香精油化合物对神经传导的抑制作用与其化学结构之间的关系,以及这些活性是否由TRP激活介导。使用气隙法记录了青蛙坐骨神经的复合动作电位(CAPs)。柠檬酸(醛)可激活各种类型的TRP通道,其半峰抑制浓度(IC50)值为0.46 mmol / L,从而减弱了CAP的峰幅度。另一醛(香茅醛),醇(香茅醇,香叶醇,(±)-芳樟醇,(-)-芳樟醇,(+)-冰片,(-)-冰片,α-萜品醇),酯(乙酸香叶酯,乙酸芳樟酯,冰片基)乙酸盐)和氧化物(氧化玫瑰)化合物也降低了CAP峰幅度(IC50:0.50、0.35、0.53、1.7、2.0、1.5、2.3、2.7、0.51、0.71、0.44和2.6 mmol / L)。另一方面,在高浓度(2-5 mmol / L)下,碳氢化合物(月桂烯和对伞花烃)和酮(樟脑)的幅度在一定程度上减小了。柠檬醛和其他TRP激动剂((+)-冰片和樟脑)的活性对TRP拮抗剂钌红有抗性。 CAP抑制的功效顺序通常为醛≥酯≥醇>氧化物烃。芳香油化合物对CAP的抑制作用与其辛醇-水分配系数无关。建议芳香油化合物以其化学结构特有的方式抑制神经传导,而不会激活TRP。

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