Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius

摘要

Two new steroids, 3α,17α,19,20-tetrahydroxy-4α-methylpregn-8-ene (>1) and 3α,12α,17α,20-tetrahydroxy-4α-methylpregn-8-ene (>2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol (>3), 3α,12-dihydroxy-δ-cadinol (>4), and 3α,6α-dihydroxyspiroax-4-ene (>5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds >3 and >4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0 % and 7.0 % at 3 × 10⁻⁴ M, respectively.Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-014-0045-z) contains supplementary material, which is available to authorized users.