The Allen Brain Atlas () provides a unique online public resource integrating extensive gene expression data, connectivity data and neuroanatomical information with powerful search and viewing tools for the adult and developing brain in mouse, human and non-human primate. Here, we review the resources available at the Allen Brain Atlas, describing each product and data type [such as in situ hybridization (ISH) and supporting histology, microarray, RNA sequencing, reference atlases, projection mapping and magnetic resonance imaging]. In addition, standardized and unique features in the web applications are described that enable users to search and mine the various data sets. Features include both simple and sophisticated methods for gene searches, colorimetric and fluorescent ISH image viewers, graphical displays of ISH, microarray and RNA sequencing data, Brain Explorer software for 3D navigation of anatomy and gene expression, and an interactive reference atlas viewer. In addition, cross data set searches enable users to query multiple Allen Brain Atlas data sets simultaneously. All of the Allen Brain Atlas resources can be accessed through the Allen Brain Atlas data portal.
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机译:艾伦大脑图集()提供了一个独特的在线公共资源,该资源将广泛的基因表达数据,连接性数据和神经解剖信息与功能强大的搜索和查看工具集成在一起,用于成年人和正在发育中的小鼠,人类和非人类灵长类动物的大脑。在这里,我们回顾了艾伦脑图集上的可用资源,描述了每种产品和数据类型(例如原位杂交(ISH)并支持组织学,微阵列,RNA测序,参考图集,投影图和磁共振成像)。另外,还描述了Web应用程序中的标准化和独特功能,这些功能使用户可以搜索和挖掘各种数据集。功能包括简单和复杂的基因搜索方法,比色和荧光ISH图像查看器,ISH的图形显示,微阵列和RNA测序数据,用于3D解剖结构和基因表达导航的Brain Explorer软件以及交互式参考图集查看器。此外,跨数据集搜索使用户可以同时查询多个艾伦大脑图集数据集。可以通过“ Allen Brain Atlas”数据门户访问所有“ Allen Brain Atlas”资源。
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