Relationship Between Chemokine Levels of the Central Nervous and Splanchnic Systems in Rats with Prehepatic Portal Hypertension

摘要

In experimental portal hypertension, the cerebral and splanchnic morphofunctional alterations could have an interrelated inflammatory etiopathogenesis mediated by chemokines. CX3CR1 overexpression in the ileum and fractalkine upregulated levels in the mesenteric ganglia may suggest a role of anti-inflammatory and repair mechanisms to compensate the action of pro-inflammatory mediators. Increased SDF1-alpha levels in the hippocampus and cerebellum could suggest the involvement of this chemokine in neuronal rearrangements. The existence of a communication mechanism chemokine-dependent through the splanchnic-brain axis in portal hypertension could be hypothesized.