Predicting neurocognitive function with hippocampal volumes and DTI metrics in patients with Alzheimers dementia and mild cognitive impairment

摘要

IntroductionCognitive performance in patients with Alzheimer's dementia (AD) and mild cognitive impairment (MCI) has been reported to be related to hippocampal atrophy and microstructural changes in white matter (WM). We aimed to predict the neurocognitive functions of patients with MCI or AD using hippocampal volumes and diffusion tensor imaging (DTI) metrics via partial least squares regression (PLSR).