Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9

摘要

BackgroundReproductive research is quintessential in understanding not only the cause of infertility, but also for creating family planning tools. The knockout (KO) system approach is conducive to discovering genes that are essential for fertility in mice. However, in vivo research has been limited due to its high cost and length of time needed to establish KO mice.