Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

摘要

Background ¹⁷⁷Lu-[DOTA⁰, Tyr³]-octreotate (¹⁷⁷Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regulate the expression of SSTR1, 2 and 5, and increase ¹⁷⁷Lu-octreotate uptake.The aim of the present study was to examine the anti-tumor effect of a ¹⁷⁷Lu-octreotate priming dose followed 24 h later by a second injection of ¹⁷⁷Lu-octreotate compared to a single administration of ¹⁷⁷Lu-octreotate, performed on the human small intestine neuroendocrine tumor cell line, GOT1, transplanted to nude mice.