miR‐34a/BCL‐2 signaling axis contributes to apoptosis in MPP+‐induced SH‐SY5Y cells

摘要

BackgroundParkinson's disease (PD) is a neurodegenerative disorder which mainly affects the elderly population of various societies. The main hallmark of this disease is the loss of dopaminergic (DA) neurons. So far, numerous studies have implied the role of microRNAs in fine‐tuning cellular processes including apoptosis. Studies have also shown that miR‐34a is mainly involved in age‐related disorders including Alzheimer's disease, and its expression is usually higher in the brain sample patients. Furthermore, the key role of miR‐34a in the expression of BCL‐2, and thus, in vitro and in vivo apoptosis has been revealed. miR‐34a/BCL‐2 axis is therefore of critical importance in inducing or inhibiting apoptosis.