首页> 外国专利> APOPTOSIS INDUCING PRODUCT AND METHOD FOR MANUFACTURING SAME, APOPTOSIS INDUCER AND METHOD OF APOPTOSIS INDUCING, INDUCER FOR DIFFERENTIATION OF CANCEOUS CELLS, FOOD PRODUCT, PHARMACEUTICAL COMPOSITIONS AND HYGIENIC MEANS

APOPTOSIS INDUCING PRODUCT AND METHOD FOR MANUFACTURING SAME, APOPTOSIS INDUCER AND METHOD OF APOPTOSIS INDUCING, INDUCER FOR DIFFERENTIATION OF CANCEOUS CELLS, FOOD PRODUCT, PHARMACEUTICAL COMPOSITIONS AND HYGIENIC MEANS

机译:凋亡诱导产物及其制造方法,凋亡诱导物和凋亡诱导方法,用于区分癌细胞,食品,药物成分和卫生手段的诱导剂

摘要

1. An apoptosis inducing product obtained by heating at a temperature from room to 350 degree C for several seconds to several days under acidic to neutral conditions at least one substance selected from the following (a), (b) and (c): (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative. 2. A product according to claim 1 wherein uronic acid is galacturonic acid, glucuronic acid, guluronic acid, mannuronic acid and/or iduronic acid. 3. A product according to claim 1 wherein the derivative is uronic acid lactone, uronic acid ester, uronic acid amide or salt thereof. 4. A heat-treated product according to claim 1 wherein the saccharide compound is a saccharide compound which is selected from pectin, pectic acid, alginic acid, hyaluronic acid, heparin, fucoidan, chondroitin sulfate, chondroitin, dermatan sulfate and/or decomposed product thereof. 5. A product according to any of claims 1-4 wherein the heat-treated product is obtained by heating at 60-350 degree C for several seconds to several days. 6. A heat-treated product according to any of claims 1-5 wherein the heat-treated product is a product obtained by means of a molecular weight fractionation. 7. A food product which is characterized in containing the heat-treated product mentioned in any of claims 1-6. 8. A food product having an anticancer action which is characterized in containing the heat-treated product mentioned in any of claims 1-6. 9. Antibacterial agent which is characterized in containing any of the heat-treated product mentioned in any of claims 1-6. 10. Antiseptic agent which is characterized in containing the antibacterial agent of claim 9. 11. Dentifrice which is characterized in containing the antibacterial agent of claim 9. 12. An apoptosis-inducer which is characterized in containing the heat-treated product of claim 1-6. 13. An anticancer agent which is characterized in containing the heat-treated product of claim 1-6. 14. An inducer for differentiation of cancerous cells which is characterized in containing the heat-treated product of claim 1-6. 15. Antiulcer agent which is characterized in containing the heat-treated product of claim 1-6. 16. A method of inducing an apoptosis which is characterized in using the heat-treated product of claim 1-6 as an effective component. 17. A method for the manufacture of an apoptosis inducing product obtained by heating at a temperature from room to 350 degree C for several seconds to several days under acidic to neutral conditions at least one substance selected from the following (a), (b) and (c): (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative. 18. A method according to claim 17 wherein uronic acid is galacturonic acid, glucuronic acid, guluronic acid, mannuronic acid and/or iduronic acid. 19. A method according to claim 17 wherein the derivative is uronic acid lactone, uronic acid ester, uronic acid amide or salt thereof. 20. A method according to claim 17 wherein the saccharide compound is a saccharide compound which is selected from pectin, pectic acid, alginic acid, hyaluronic acid, heparin, fucoidan, chondroitin sulfate, chondroitin, dermatan sulfate and/or decomposed product thereof. 21. A method according to any of claims 17-20 wherein the heating is a treatment which is conducted at 60-350 degree C for several seconds to several days. 22. A method according to any of claims 17-21 wherein the heating is a treatment which is conducted under acidic to neutral conditions. 23. A method according to any of claims 17-22 wherein a step of conducting a molecular weight fractionation of the heat-treated product is included.
机译:1.通过在酸性至中性条件下于室温至350℃的温度下加热数秒至数天而获得的细胞凋亡诱导产物,所述物质选自以下(a),(b)和(c)中的至少一种: a)糖醛酸或糖醛酸衍生物; (b)含有糖醛酸的糖化合物或含有糖醛酸衍生物的糖化合物; (c)含有含有糖醛酸的糖化合物的物质或含有含有糖醛酸衍生物的糖化合物的物质。 2.根据权利要求1的产品,其中糖醛酸是半乳糖醛酸,葡糖醛酸,古洛糖醛酸,甘露糖醛酸和/或艾杜糖醛酸。 3.根据权利要求1的产品,其中所述衍生物是糖醛酸内酯,糖醛酸酯,糖醛酰胺或其盐。 4.根据权利要求1的热处理产品,其中所述糖化合物是选自果胶,果胶酸,藻酸,透明质酸,肝素,岩藻依聚糖,硫酸软骨素,软骨素,硫酸皮肤素和/或分解产物的糖化合物。其。 5.根据权利要求1-4中任一项的产品,其中所述热处理的产品通过在60-350℃下加热数秒至数天而获得。 6.根据权利要求1-5中任一项的热处理产物,其中所述热处理产物是通过分子量分馏获得的产物。 7.一种食品,其特征在于包含权利要求1-6中任一项所述的热处理产品。 8.具有抗癌作用的食品,其特征在于含有权利要求1-6中任一项所述的热处理产品。 9.抗菌剂,其特征在于,含有权利要求1-6中任何一项所述的热处理产物。 10.杀菌剂,其特征在于,其包含权利要求9的抗菌剂。11.牙粉,其特征在于,其包含权利要求9的抗菌剂。12.凋亡诱导剂,其特征在于,其包含权利要求1的热处理产物。 -6。 13.一种抗癌剂,其特征在于包含权利要求1-6的热处理产物。 14.一种用于分化癌细胞的诱导剂,其特征在于包含权利要求1-6的热处理产物。 15.抗溃疡剂,其特征在于包含权利要求1-6的热处理产物。 16.一种诱导细胞凋亡的方法,其特征在于使用权利要求1-6的热处理产物作为有效成分。 17.一种通过在酸性至中性条件下在室温至350℃下加热几秒钟至几天而获得的细胞凋亡诱导产物的制备方法,所述至少一种选自以下(a),(b)的物质(c):(a)糖醛酸或糖醛酸衍生物; (b)含有糖醛酸的糖化合物或含有糖醛酸衍生物的糖化合物; (c)含有含有糖醛酸的糖化合物的物质或含有含有糖醛酸衍生物的糖化合物的物质。 18.根据权利要求17所述的方法,其中,所述糖醛酸为半乳糖醛酸,葡糖醛酸,古洛糖醛酸,甘露糖醛酸和/或艾杜糖醛酸。 19.根据权利要求17所述的方法,其中,所述衍生物是糖醛酸内酯,糖醛酸酯,糖醛酰胺或其盐。 20.根据权利要求17所述的方法,其中,所述糖类化合物是选自果胶,果胶酸,藻酸,透明质酸,肝素,岩藻依聚糖,硫酸软骨素,软骨素,硫酸皮肤素和/或其分解产物的糖类化合物。 21.根据权利要求17-20中任一项所述的方法,其中,所述加热是在60-350℃下进行数秒至数天的处理。 22.根据权利要求17至21中任一项所述的方法,其中所述加热是在酸性至中性条件下进行的处理。 23.根据权利要求17-22中任一项所述的方法,其中包括进行所述热处理产物的分子量分级的步骤。

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