Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice

机译：皂素治疗可预防小鼠妊娠前糖尿病诱发的先天性心脏病

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BackgroundTetrahydrobiopterin is a cofactor of endothelial NO synthase (eNOS), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects (CHDs) induced by pregestational diabetes mellitus in mice.

机译：背景四氢生物蝶呤是内皮一氧化氮合酶（eNOS）的辅因子，对胚胎心脏发育至关重要。我们旨在研究sapropterin（Kuvan）（一种四氢生物蝶呤的口服活性合成形式）对小鼠妊娠前糖尿病引起的eNOS解偶联和先天性心脏缺陷（CHD）的影响。

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期刊名称 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
作者
Anish Engineer; Tana Saiyin; Xiangru Lu; Andrew S. Kucey; Brad L. Urquhart; Thomas A. Drysdale; Kambiz Norozi; Qingping Feng;
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年(卷),期 2018(7),21
年度 2018
页码 e009624
总页数 19
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
animal model cardiovascular disease cardiac embryology congenital cardiac defect diabetes mellitus;

机译：动物模型心血管疾病;心脏胚胎学;先天性心脏缺陷;糖尿病;

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专利

1. N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes [J] . Hoda Moazzen, Xiangru Lu, Noelle L Ma, Cardiovascular Diabetology . 2014,第1期

机译：N-乙酰半胱氨酸可预防妊娠糖尿病引起的先天性心脏病
2. Pregestational Diabetes Mellitus and Congenital Heart Defects [J] . Correa Adolfo Circulation: An Official Journal of the American Heart Association . 2016,第23期

机译：孕前糖尿病和先天性心脏病
3. Pregestational Diabetes Mellitus and Congenital Heart Defects [J] . Correa Adolfo Circulation: An Official Journal of the American Heart Association . 2016,第23期

机译：孕前糖尿病和先天性心脏病
4. Hepar Histology of Mice (Mus musculus L) Indicated by Pre-Diabetes Mellitus Type 2 (Pre-Type 2 DM) After Red Rice Yeast Treatment [C] . Rudiana Agustini, Erlix Rakhmad Purnomo, Agus Widodo Mathematics, Informatics, Science, and Education International Conference . 2019

机译：小鼠蛋白酶蛋白酶蛋白酶蛋白（预型2 DM）所示的小鼠（Mus Musculus L）的组织学
5. THE EFFECT OF ANTI-LYMPHOCYTE SERUM, LEVAMISOLE AND INDOMETHACIN ON VIRAL-INDUCED DIABETES MELLITUS BY ENCEPHALO-MYOCARDITIS - VARIANT M (EMC-M) INFECTION IN DBA/2J MALE MICE. [D] . WARCHALOWSKI, GEORGE ALEXANDER. 1978

机译：脑脊髓炎-变异M（EMC-M）感染DBA / 2J雄性小鼠的抗淋巴细胞血清，左旋咪唑和吲哚美辛对病毒诱导的糖尿病的影响。
6. N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes [O] . Hoda Moazzen, Xiangru Lu, Noelle L Ma, 2014

机译：N-乙酰半胱氨酸可预防妊娠糖尿病引起的先天性心脏病
7. Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes in Mice [O] . Anish Engineer, Tana Saiyin, Xiangru Lu, 2018

机译：Sapropterin治疗可防止在小鼠中引起的先天性心脏缺陷

Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice

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