Hepar Histology of Mice (Mus musculus L) Indicated by Pre-Diabetes Mellitus Type 2 (Pre-Type 2 DM) After Red Rice Yeast Treatment

摘要

The hepar is an organ that has a complex and vital role, which can be damaged. Hepar damage can be seen from the condition of the cells. His study aimed to provide a histological description of mice hepar (Mus musculus L.) that was indicated by pre-type 2 DM (pre-type 2 DM) after the treatment of red rice yeast was carried out. The study was conducted on male mice weighing 20-24 grams and indicated pre-Type 2 DM. the mice were grouped into six groups based on the test material given, namely: red rice, red rice yeast, Yeast hydrolysate enzymatic (YHE) - red rice, positive control (glibenclamide + CMC-Na), normal control (commercial feed + CMC) -Na), and negative control (pre type 2 DM + CMC-Na). Each group was treated with 1 ml of the test material by oral gavage, then histology of the liver was observed to determine the level of liver cell damage. Based on liver histology results of mice, it was found that the level of cell damage was indicated by the level of hepatocyte damage resulting from the treatment of red rice yeast, YHE red rice, glibenclamide + CMC Na, commercial feed + CMC Na, and pre-type 2 DM + CMC Na respectively -according to 12, 29, 47, 18, and 53%. Red rice yeast has the best ability to regenerate liver cells among the treatments given. This result can be seen from the smallest level of red rice yeast hematocyte damage, which is 12% and the largest is negative control (53%), namely mice with type 2 DM and given CMC Na feed.