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Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet

机译：成年人和儿科继发性甲状旁腺功能亢进症接受血液透析的连接：西那卡塞的药代动力学-药效学分析

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摘要

AimsThe aims of this study were to develop a pharmacokinetic (PK) and PK‐pharmacodynamic (PK/PD) model of cinacalcet in adults and paediatrics with secondary hyperparathyroidism (SHPT) on dialysis, to test covariates of interest, and to perform simulations to inform dosing in paediatrics with SHPT.

机译：目的本研究的目的是建立透析中继发性甲状旁腺功能亢进症（SHPT）的成人和儿科西那卡塞的药代动力学（PK）和PK药效学（PK / PD）模型，以测试相关协变量，并进行模拟以告知SHPT在儿科中给药。

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期刊名称 British Journal of Clinical Pharmacology
作者
Ping Chen; Winnie Sohn; Adimoolam Narayanan; Per Olsson Gisleskog; Murad Melhem;
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作者单位

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年(卷),期 2019(85),6
年度 2019
页码 1312–1325
总页数 14
原文格式 PDF
正文语种
中图分类药学;
关键词
chronic kidney disease dialysis modelling and simulation paediatrics PK/PD;

机译：慢性肾脏病;透析;建模与模拟;儿科;PK / PD;

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专利

1. Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet [J] . Ping Chen, Winnie Sohn, Adimoolam Narayanan, British journal of clinical pharmacology . 2019,第6期

机译：成年人和儿科继发甲状旁腺功能亢进症接受血液透析的连接：西那卡塞的药代动力学-药效学分析
2. Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet [J] . Chen Ping, Sohn Winnie, Narayanan Adimoolam, British Journal of Clinical Pharmacology . 2019,第6期

机译：伴有继发性甲状旁腺功能亢进的成人和儿科，接受血液透析性：Cinacalcet的药代动力学 - 药物动力学分析
3. Paricalcitol- or cinacalcet-centred therapy affects markers of bone mineral disease in patients with secondary hyperparathyroidism receiving haemodialysis: Results of the IMPACT-SHPT study [J] . CozzolinoM., KettelerM., MartinK.J., Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2014,第4期

机译：以paricalcitol或cinacalcet为中心的疗法影响接受血液透析的继发性甲状旁腺功能亢进患者的骨矿物质疾病标志物：IMPACT-SHPT研究结果
4. In Vivo Pharmacokinetic/pharmacodynamic analysis of firstgeneration anticoagulant rodenticide warfarin with Egyptian fruit bats (Rousettus aegyptiacus) for risk assessment of Bonin fruit bats (Pteropus pselaphon) [C] . Shouta M.M. Nakayama, Kosuke Manago, Kazuki Takeda 環境化学討論会要旨集 . 2019

机译：体内药代动力学/药效学分析埃及抗凝血剂的埃及抗凝血剂冠状动脉释放肽（Rousettus Aegyptiacus）的风险评估（Pteropus Pselaphon）
5. Bioanalysis and pharmacokinetics-pharmacodynamics modeling of the endogenous 2'deoxynucleoside triphosphate pool in individuals receiving tenofovir/emtricitabine. [D] . Chen, Xinhui. 2016

机译：接受替诺福韦/恩曲他滨治疗的个体中内源性2'脱氧核苷三磷酸池的生物分析和药代动力学-药效学建模。
6. Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study [O] . Markus Ketteler, Kevin J. Martin, Myles Wolf, -1

机译：Paricalcitol与Cinacalcet联合小剂量维生素D治疗血液透析患者继发性甲状旁腺功能亢进：IMPACT SHPT研究的结果
7. Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet [O] . Ping Chen, Winnie Sohn, Adimoolam Narayanan, 2019

机译：伴有继发性甲状旁腺功能亢进的成人和儿科，接受血液透析性：Cinacalcet的药代动力学 - 药物动力学分析

Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet

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