BIOREACTOR SYSTEM FOR PHARMACOKINETIC-PHARMACODYNAMIC ANALYSIS

摘要

The invention provides an in vitro cell culturing bioreactor device capable of supporting the growth of protozoan parasites, such as, for example species of the genera Trypanosoma, Toxoplasma, Leishmania, and Plasmodium, but which can also be utilized to grow other cell types, including, for example, cancer cells, virus-infected cells, bacteria, and mycobacteria. The invention also provides methods for monitoring and/or measuring the effects of therapeutic agents on cells, for determining the pharmacokinetic- pharmacodynamic relationship between a drug and a target cell, and for determining an effective dosing regime for a drug or therapeutic agent.