IntroductionCystic fibrosis (CF) is a genetic disease resulting in changes to the functioning of a transmembrane sodium transporter at mucosal surfaces and subsequent multisystem disease. Roughly 10,500 people in the UK live with CF, and life expectancy has improved markedly in the last few decades. Lung disease with bronchiectasis, chronic infection and progressive respiratory failure is accompanied by gastrointestinal, hepatic, pancreatic, and metabolic bone complications. An inflammatory arthritis known as cystic fibrosis associated arthritis (CFA), has been described in episodic and chronic forms for nearly 40 years now but remains without formal definition or an evidence base for treatment.
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