Body fat is an important source of adipokine, which is associated with energy balance and inflammatory and immune responses. However, the role of adipokines in coronary artery complications in Kawasaki disease (KD) has not yet been fully explained. We investigated whether serum adipokine level can be a useful marker for patients with KD who are at higher risk of developing coronary artery lesion (CAL). We measured adipokine levels and other inflammatory parameters in 40 patients with KD, 32 febrile controls, and 15 afebrile controls. Interleukin (IL)-6, tumor necrosis factor (TNF)-α and other laboratory parameters were also measured before and after intravenous immunoglobulin therapy, and in the convalescent phase. At admission, the serum resistin levels in KD children were significantly higher than those in controls (177.56 ng/mL in KD children, 76.48 ng/mL in febrile controls, and 17.95 ng/mL in afebrile controls). In patients with KD, resistin levels were significantly associated with decreased hemoglobin levels (P=0.049) and increased IL-6 levels (P=0.014). The serum IL-6 levels were significantly higher and body mass index was significantly lower in the group of KD with CALs than those without CALs (228.26 ng/mL vs. 39.18 ng/mL and 15.09 vs. 16.60, respectively). In conclusion, resistin is significantly elevated in KD patients, although it has no prognostic value of predicting coronary artery lesion in the acute stage.Graphical Abstract
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机译：体内脂肪是脂肪因子的重要来源，脂肪与能量平衡以及炎症和免疫反应有关。然而，尚未完全阐明脂肪因子在川崎病（KD）中冠状动脉并发症中的作用。我们调查了血清脂肪因子水平是否可以作为罹患冠心病（CAL）风险较高的KD患者的有用标志物。我们在40例KD患者，32例发热对照和15例发热对照中测量了脂肪因子水平和其他炎症参数。在静脉内免疫球蛋白治疗之前和之后以及恢复期也测量了白细胞介素（IL）-6，肿瘤坏死因子（TNF）-α和其他实验室参数。入院时，KD患儿的血清抵抗素水平显着高于对照组（KD患儿为177.56 ng / mL，发热对照为76.48 ng / mL，发热对照为17.95 ng / mL）。在KD患者中，抵抗素水平与血红蛋白水平降低（P = 0.049）和IL-6水平升高（P = 0.014）显着相关。有CAL的KD组的血清IL-6水平显着较高，而体重指数则显着低于没有CAL的KD组（分别为228.26 ng / mL，39.18 ng / mL和15.09 vs. 16.60）。总之，抵抗素在KD患者中显着升高，尽管它没有预测急性期冠状动脉病变的预后价值。
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