首页> 美国卫生研究院文献>Scientific Reports >A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery
【2h】

A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery

机译:无补丁溶解微针输送系统可快速有效地进行透皮药物输送

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report “Microlancer”, a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.
机译:溶解性微针(DMN)是聚合的微观针,可以以微创的方式递送封装的药物。当前,DMN阵列被叠加在有助于其插入皮肤的贴片上。然而,由于皮肤弹性和皮肤上的毛发量的广泛变化,在贴片上制造的阵列常常不能完全插入,并且不能输送大量的负载材料。在这里,我们报告“ Microlancer”,这是一种基于微柱的新型系统,患者可以通过该系统自我管理DMN,并且无论皮肤类型或皮肤上的头发量如何,该系统都能够实现所装载药物的97±2%输送效率。不到一秒钟的皮肤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号