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A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery

机译:无毛的溶解微针递送系统,可快速高效的透皮药物递送

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Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report “Microlancer”, a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 ± 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.
机译:溶解微针(DMN)是聚合物,微观针头以微创方式递送封装的药物。目前,DMN阵列叠加在促进其插入皮肤的贴片上。然而,由于皮肤弹性的宽变化和皮肤上的头发的量,在贴片上制造的阵列通常不会完全插入,并且不会递送大量的负载材料。在这里,我们报告“微洛尔施”,一种新型的基于微量的系统系统,患者可以自适应DMNS,并且在不论皮肤型或头发上,也能够实现装载药物的97±2%的输送效率。皮肤不到一秒。

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