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Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors

机译：β-抑制蛋白泛素在激动剂促进的M1和M2毒蕈碱乙酰胆碱受体下调中的不同作用

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BackgroundSustained agonist-promoted ubiquitination of β-arrestin has been correlated with increased stability of the GPCR – β-arrestin complex. Moreover, abrogation of β-arrestin ubiquitination has been reported to inhibit receptor internalization with minimal effects on receptor degradation.

机译：背景持续的激动剂促进的β-arrestin泛素化与GPCR-β-arrestin复合物的稳定性增加相关。此外，据报废除β-arrestin泛素化可抑制受体内在化，而对受体降解的影响最小。

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期刊名称 Journal of Molecular Signaling
作者
Valerie A Mosser; Kymry T Jones; Katie M Hoffman; Nael A McCarty; Darrell A Jackson;
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年(卷),期 2008(3),-1
年度 2008
页码 20
总页数 13
原文格式 PDF
正文语种
中图分类分子生物学 ;
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专利

1. Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors [J] . Valerie A Mosser, Kymry T Jones, Katie M Hoffman, Journal of molecular signaling . 2008 ,第1期

机译：β-抑制蛋白泛素在激动剂促进的M1和M2毒蕈碱乙酰胆碱受体下调中的不同作用
2. Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the α subunit of the G-protein Gq [J] . G Milligan, I Mullaney, M W Dodd, The biochemical journal . 1993 ,第1期

机译：CHO细胞中转染的人M1毒蕈碱型乙酰胆碱受体的激动剂激活导致该受体和G蛋白Gq的α亚基下调
3. Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343. [J] . Suga H, Sawyer GW, Ehlert FJ Molecular pharmacology. . 2010 ,第4期

机译：M1和M2毒蕈碱受体正链结合袋附近亲核残基的诱变：对乙酰胆碱和McN-A-343氮芥类似物结合的影响。
4. Cholinergic Modulation of CA1 Pyramidal Cells via M1 Muscarinic Receptor Activation: A Computational Study at Physiological and Supraphysiological Levels [C] . Adam R. Mergenthal, Jean-Marie C. Bouteiller, Theodore W. Berger Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：通过M1毒蕈碱受体激活对CA1锥体细胞的胆碱能调节：生理和超生理水平的计算研究。
5. An in vivo biosensor for neurotransmitter release and in situ receptor activity: Acetylcholine and the M1 muscarinic receptor. [D] . Schroeder, Lee Frederick. 2009

机译：用于神经递质释放和原位受体活性的体内生物传感器：乙酰胆碱和M1毒蕈碱受体。
6. Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq. [O] . I Mullaney, M W Dodd, N Buckley, 1993

机译：CHO细胞中转染的人M1毒蕈碱型乙酰胆碱受体的激动剂激活导致该受体和G蛋白Gq的α亚基下调。
7. Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors [O] . Mosser, Valerie A, Jones, Kymry T, Hoffman, Katie M, 2008

机译：β-抑制蛋白泛素在激动剂促进的M1和M2毒蕈碱乙酰胆碱受体下调中的不同作用

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors

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