Predicting 131I-avidity of metastases from differentiated thyroid cancer using 18F-FDG PET/CT in postoperative patients with elevated thyroglobulin

摘要

The quantitative relationship between iodine and glucose metabolism in metastases from differentiated thyroid cancer (DTC) remains unknown. Aim of the prospective study was to establish the value of ¹⁸F-FDG PET/CT in predicting ¹³¹I-avidity of metastases from DTC before the first radioiodine therapy. A total of 121 postoperative DTC patients with elevated stimulated serum thyroglobulin (ssTg) who underwent ¹³¹I adjuvant therapy or therapy after ¹⁸F-FDG PET/CT scan were enrolled. The Receiver operating characteristic curve was established to create an optimal cut-off point and evaluate the value of SUVmax for predicting ¹³¹I-avidity. In our study, the median SUVmax in ¹³¹I-nonavid metastatic target lesions was also significantly higher than that in ¹³¹I-avid metastatic target lesions (5.37 vs. 3.30; P = 0.000). At a cut-off value of 4.0 in SUVmax, the area under curve was 0.62 with the sensitivity, specificity, positive predictive value and negative predictive value of 75.3%, 56.7%, 76.1%, and 54.8%, respectively. These results suggest that ¹⁸F-FDG PET/CT may be of great value in identifying metastases in postoperative DTC patients with elevated ssTg before ¹³¹I administration, leading to an improved management of disease. ¹⁸F-FDG positive metastatic DTC with SUVmax of greater than 4.0 possesses higher probability of non-avidity to radioiodine.