Production and in vivo PET/CT imaging of the theranostic pair 132/135La

摘要

The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added ^132/135La³⁺ from bulk ^natBa. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbqmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced ^132/135La³⁺ has a radiochemical and radionuclidic purity amenable for ¹³²La/¹³⁵La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting ¹³²La and ex vivo biodistribution data separately corroborated the accumulation of unchelated ^132/135La³⁺ ions in bone and the liver.