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A Randomized Double-Blind Placebo-Controlled Study of an Oral Extended-Release Formulation of Phentermine/Topiramate for the Treatment of Obstructive Sleep Apnea in Obese Adults

机译：芬特明/托吡酯口服缓释制剂治疗肥胖成人阻塞性睡眠呼吸暂停的随机双盲安慰剂对照研究

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摘要

Study Objectives:To evaluate safety and efficacy of phentermine 15 mg plus extended-release topiramate 92 mg for treatment of moderate to severe obstructive sleep apnea (OSA) in obese adults.

机译：研究目的：评价芬特明15 mg加缓释托吡酯92 mg治疗肥胖成人中度至重度阻塞性睡眠呼吸暂停（OSA）的安全性和有效性。

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期刊名称 Sleep
作者
David H. Winslow; Charles H. Bowden; Karen P. DiDonato; Pamela A. McCullough;
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作者单位

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年(卷),期 2012(35),11
年度 2012
页码 1529–1539
总页数 14
原文格式 PDF
正文语种
中图分类精神病学;
关键词
Obstructive sleep apnea phentermine topiramate obesity apnea-hypopnea index;

机译：阻塞性睡眠呼吸暂停;芬特明;托吡酯;肥胖;呼吸暂停低通气指数;

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专利

1. A randomized, double-blind, placebo-controlled study of an oral, extended-release formulation of phentermine/topiramate for the treatment of obstructive sleep apnea in obese adults [J] . WinslowD.H., BowdenC.H., DiDonatoK.P., Sleep . 2012,第11期

机译：芬特明/托吡酯口服延长释放制剂治疗肥胖成人阻塞性睡眠呼吸暂停的随机，双盲，安慰剂对照研究
2. Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults. [J] . Roth T, White D, Schmidt Nowara W, Clinical therapeutics . 2006,第5期

机译：阿莫达非尼对与阻塞性睡眠呼吸暂停/呼吸不足综合征相关的残余过度嗜睡的治疗作用：一项为期12周的多中心，双盲，随机，安慰剂对照研究，研究对象为nCPAP坚持的成年人。
3. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. [J] . Garvey WT, Ryan DH, Look M, The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2012,第2期

机译：肥胖和超重成年人（SEQUEL）中的芬特明/托吡酯控释可维持两年的持续减肥和代谢益处：一项随机，安慰剂对照的3期扩展研究。
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A randomized, double-blind, placebo-controlled, clinical trial of curcuminoids in oral lichen planus. [D] . Wu, Nita Chainani. 2005

机译：口服扁平苔藓中姜黄素类药物的随机，双盲，安慰剂对照临床试验。
6. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized placebo-controlled phase 3 extension study [O] . W Timothy Garvey, Donna H Ryan, Michelle Look, -1

机译：肥胖和超重成年人（SEQUEL）中的芬特明/托吡酯控释可维持两年的持续减肥和代谢益处（一项随机安慰剂对照3期扩展研究）
7. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study123 [O] . Garvey, W Timothy, Ryan, Donna H, Look, Michelle, 2011

机译：肥胖和超重成年人（SEQUEL）中使用芬特明/托吡酯控释的两年持续减肥和代谢益处（SEQUEL）：一项随机，安慰剂对照的3期扩展研究123

A Randomized Double-Blind Placebo-Controlled Study of an Oral Extended-Release Formulation of Phentermine/Topiramate for the Treatment of Obstructive Sleep Apnea in Obese Adults

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